Scientists from Institut Necker-Enfants-Malades (INSERM/CNRS unit at the University Paris Descartes), discovered a molecule called ADAM10 becomes active and prevents our body’s natural ability to stop uncontrollable blood clotting in meningococcal disease.
Their findings published in PLOS Pathogens, funded by Meningitis Research Foundation (MRF) may help develop treatments to prevent amputations & death.
Linda Glennie, Director of Research at MRF said, “Meningococcal meningitis and septicemia are deadly diseases that strike without warning …. This research is really exciting as it’s the first time that the link has been identified between meningococcal adhesion to cells lining the blood vessels, and widespread, disastrous blood-clotting. It brings us a step closer to finding a treatment that could stop purpura fulminans in its tracks and enable patients to survive meningococcal disease unscathed.”
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